Archives of Pharmacal Research, 2006, 29(4), , pp.265-275
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Blood-brain barrier interfaces and brain tumors
- Ist Teil von
- Archives of Pharmacal Research, 2006, 29(4), , pp.265-275
- Ort / Verlag
- Korea (South): 대한약학회
- Erscheinungsjahr
- 2006
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0253-6269eISSN: 1976-3786DOI: 10.1007/bf02968569Titel-ID: cdi_nrf_kci_oai_kci_go_kr_ARTI_1139345
- Format
- –
- Schlagworte
- Animals, Astrocytes - metabolism, Astrocytes - pathology, Blood-Brain Barrier - embryology, Blood-Brain Barrier - metabolism, Blood-Brain Barrier - pathology, Brain - blood supply, Brain - embryology, Brain - metabolism, Brain Neoplasms - blood supply, Brain Neoplasms - metabolism, Brain Neoplasms - pathology, Cell Communication, Cell Differentiation, Cell Hypoxia, Endothelial Cells - metabolism, Endothelial Cells - pathology, Humans, Neovascularization, Physiologic, Pericytes - metabolism, Pericytes - pathology, Vascular Endothelial Growth Factors - metabolism, 약학