Details

Autor(en) / Beteiligte

• Kwon, Suk Hyung
• Kim, Sun Young
• Ha, Kyoung Wook
• Kang, Myung Joo
• Huh, Jin Seo
• Im, Tae Jong
• Kim, Yong Min
• Park, Young Mi
• Kang, Kyoung Hoon
• Lee, Sangkil
• Chang, Jung Yun
• Lee, Jaehwi
• Choi, Young Wook

Titel

Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery

Ist Teil von

• Archives of Pharmacal Research, 2007, 30(9), , pp.1138-1143

Ort / Verlag

Korea (South): 대한약학회

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of PEO100-PPO65-PEO100. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genistein-loaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein.