Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo
Ist Teil von
Archives of Pharmacal Research, 2010, 33(9), , pp.1317-1323
Ort / Verlag
Heidelberg: Pharmaceutical Society of Korea
Erscheinungsjahr
2010
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Five compounds previously known structures, scopoletin (
1
), northalifoline (
2
), stigmast-4-en-3-one (
3
), tiliroside (
4
), and oplopanone (
5
) were obtained from the flower buds of
Magnolia fargesii
using chromatographic separation methods. The structures of
1
–
5
were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds
1
–
3
were found from
M. fargesii
for the first time in this study. All the isolates (
1
–
5
) were subjected to
in vitro
bioassays to evaluate the inhibitory activity on advanced glycation end products formation and rat lens aldose reductase (RLAR). Compound
1
showed a remarkable inhibitory activity on advanced glycation end products formation with IC
50
value of 2.93 μM (aminoguanidine: 961 μM), and showed a significant RLAR inhibitory activity with IC
50
value of 22.5 μM (3.3-tetramethyleneglutaric acid: 28.7 μM). Compound
4
exhibited potent inhibitory activity against RLAR (IC
50
= 14.9 μM). In the further experiment
ex vivo
, cataractogenesis of rat lenses induced with xylose was significantly inhibited by compound
1
treatment.