Details

Autor(en) / Beteiligte

• 신대환(Dae Hwan Shin)
• 김태성(Tai Sung Kim)
• 박승혁(Seong Hyeok Park)
• 김시현(Si Hyun Kim)
• 조한준(Han Jun Jo)
• 한건(Kun Han)
• 정연복(Youn Bok Chung)

Titel

흰쥐에서 이부프로펜 리신염의 물리화학적 특성 및 약물동태에 관한 평가

Ist Teil von

• 약 학 회 지, 2011, 55(3), , pp.260-266

Ort / Verlag

The Pharmaceutical Society Of Korea

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Two types of water soluble lysine salts of ibuprofen were prepared and evaluated. Physicochemical properties for ibuprofen-l-lysinate (IBL-l), ibuprofen-dl-lysinate (IBL-dl) and ibuprofen (IB) were studied on melting point, specific ratation, UV spectra and $^1H$-NMR spectra. There were not differences between IBL-dl and IBL-l in UV spectra and $^1H$-NMR spectra. The pharmacokinetic parameters of IB were compared to those of its lysine salts (IBL-l and IBL-dl) after i.v. or oral administration at the dose of 50 mg/kg (calculated as IB). Total body clearance ($CL_t$) and area under the plasma concentration-time curve (AUC) were not different between IB group and IBL groups after i.v. administration. On the other hand, IBL-l and IBL-dl produced peak plasma concentrations ($C_{max}$) significantly ealier and higher than IB. Time to reach peak concentration ($T_{max}$) after IBL administration was lower than that after IB administration. There was no difference in AUC across all different groups (IB, IBL-l and IBL-dl) after oral administration. However, absorption rate constant ($k_a$) of IBL-l and IBL-dl were significantly increased than that of IB. These results indicated that the administration of IBL-l and IBL-dl may be advantageous if rapid and reliable onset of pain relief is required.