Details

Autor(en) / Beteiligte

• Kang, H., Incheon National University, Incheon, Republic of Korea
• Hata, A., University of California, San Francisco, USA

Titel

The role of microRNAs in cell fate determination of mesenchymal stem cells : balancing adipogenesis and osteogenesis

Ist Teil von

• BMB Reports, 2015, 48(6), , pp.319-323

Ort / Verlag

Korea (South): Korean Society for Biochemistry and Molecular Biology

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into adipocytes, osteoblasts, or chondrocytes. A mutually inhibitory relationship exists between osteogenic and adipogenic lineage commitment and differentiation. Such cell fate decision is regulated by several signaling pathways, including Wnt and bone morphogenetic protein (BMP). Accumulating evidence indicates that microRNAs (miRNAs) act as switches for MSCs to differentiate into either osteogenic or adipogenic lineage. Different miRNAs have been reported to regulate a master transcription factor for osteogenesis, such as Runx2, as well as molecules in the Wnt or BMP signaling pathway, and control the balance between osteoblast and adipocyte differentiation. Here, we discuss recent advancement of the cell fate decision of MSCs by miRNAs and their targets.