Details

Autor(en) / Beteiligte

• Sha, Wei Hong
• Zeng, Xiao Hui
• Min, Lu

Titel

The correlation between NK cell and liver function in patients with primary hepatocellular carcinoma

Ist Teil von

• Gut and Liver, 2014, 8(3), , pp.298-305

Ort / Verlag

Korea (South): The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Association for the Study of the Liver, the Korean Society of Neurogastroenterology and Motility, Korean Association for the Study of Intestinal Diseases, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Pancreatobiliary Association, Korean Society of Gastrointestinal Cancer

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to detect the expression of natural killer (NK) cell receptor natural killer group 2D (NKG2D) in the peripheral blood of patients with primary hepatocellular carcinoma and to discuss the correlation between NK cell cytotoxicity and liver function. The number of NK cells and the expression of NK cell receptor NKG2D in peripheral blood were determined by flow cytometry in patients with primary hepatocellular carcinoma, hepatitis B cirrhosis, chronic hepatitis B, and healthy controls. When compared with patients in the healthy and the chronic hepatitis B groups, the primary hepatocellular carcinoma group showed significant decreases in all parameters, including the cytotoxicity of NK cells on K562 cells, expression rate of NKG2D in NK cells, number of NKG2D(+) NK cells, expression level of NKG2D, and number of NK cells (p<0.05). The activity of NK cells showed a positive correlation, whereas the Child-Pugh scores in the primary hepatocellular carcinoma and the hepatitis B cirrhosis groups showed a negative correlation with all parameters detected above. The decrease of NK cell activity in patients with primary hepatocellular carcinoma is closely related to their lower expression of NKG2D. Liver function affects the expression of NKG2D and the activity of NK cells.