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Interfaces between dendritic cells, other immune cells, and nerve fibres in mouse Peyer's patches: Potential sites for neuroinvasion in prion diseases
Microscopy research and technique, 2005-01, Vol.66 (1), p.1-9
Defaweux, Valérie
Dorban, Gauthier
Demonceau, Caroline
Piret, Joëlle
Jolois, Olivier
Thellin, Olivier
Thielen, Caroline
Heinen, Ernst
Antoine, Nadine
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Defaweux, Valérie
Dorban, Gauthier
Demonceau, Caroline
Piret, Joëlle
Jolois, Olivier
Thellin, Olivier
Thielen, Caroline
Heinen, Ernst
Antoine, Nadine
Titel
Interfaces between dendritic cells, other immune cells, and nerve fibres in mouse Peyer's patches: Potential sites for neuroinvasion in prion diseases
Ist Teil von
Microscopy research and technique, 2005-01, Vol.66 (1), p.1-9
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
In this study, we examined where immune cells and nerve fibres are located in mouse Peyer's patches, with a view to identifying potential sites for neuroinvasion by prions. Special attention was paid to dendritic cells, viewed as candidate transporters of infectious prion. Double immunofluorescence labellings with anti‐CD11c antibody and marker for other immune cells (B cells, T cells, follicular dendritic cells) were carried out and analysed by confocal microscopy on Peyer's patch cryosections. To reveal the extensive ganglionated networks of the myenteric and submucosal plexi and the sparse meshworks of nerve strands, we used antibodies directed against different neurofilament subunits or against glial fibrillary acidic protein. In the suprafollicular dome, dendritic cells connect, via their cytoplasmic extensions, enterocytes with M cells of the follicle‐associated epithelium. They are also close to B and T cells. Nerve fibres are detected in the suprafollicular dome, notably in contact with dendritic cells. Similar connections between dendritic cells, T cells, and nerve fibres are seen in the interfollicular region. Germinal centres are not innervated; inside them dendritic cells establish contacts with follicular dendritic cells and with B cells. After immunolabelling of normal prion protein, dendritic cells of the suprafollicular dome are intensely positive labelled. Microsc. Res. Tech. 66:1–9, 2005. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1059-910X, 1097-0029
eISSN: 1097-0029
DOI: 10.1002/jemt.20135
Titel-ID: cdi_liege_orbi_v2_oai_orbi_ulg_ac_be_2268_7136
Format
–
Schlagworte
Anatomie (cytologie, histologie, embryologie...) & physiologie
,
Anatomy (cytology, histology, embryology...) & physiology
,
Animals
,
CD11c Antigen - metabolism
,
dendritic cells
,
Dendritic Cells - metabolism
,
Fluorescent Antibody Technique
,
follicular dendritic cells
,
Frozen Sections
,
Life sciences
,
Mice
,
Mice, Inbred C57BL
,
mouse
,
Nerve Fibers - metabolism
,
nerve fibres
,
Peyer's patches
,
Peyer's Patches - metabolism
,
prion
,
PrPC Proteins - metabolism
,
Sciences du vivant
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