Details

Autor(en) / Beteiligte

• Nguyen, Laurent
• Borgs, Laurence
• Vandenbosch, Renaud
• Mangin, Jean-Marie
• Beukelaers, Pierre
• Moonen, Gustave
• Gallo, Vittorio
• Malgrange, Brigitte
• Belachew, Shibeshih

Titel

The Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage

Ist Teil von

• Mental retardation and developmental disabilities research reviews, 2006, Vol.12 (2), p.85-96

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor cells involves errors in the sequence of events that normally occur during development when progenitors proliferate, migrate through the white matter, contact the axon, and differentiate into myelin‐forming oligodendrocytes. Multiple mechanisms underlie the eventual progressive deterioration that typifies the natural history of developmental demyelination in LD and PVL and of adult‐onset demyelination in MS. Over the past few years, pathophysiological studies have mostly focused on seeking abnormalities that impede oligodendroglial maturation at the level of migration, myelination, and survival. In contrast, there has been a strikingly lower interest for early proliferative and differentiation events that are likely to be equally critical for white matter development and myelin repair. This review highlights the Yin and Yang principles of interactions between intrinsic factors that coordinately regulate progenitor cell division and the onset of differentiation, i.e. the initial steps of oligodendrocyte lineage progression that are obviously crucial in health and diseases. MRDD Research Reviews 2006;12:85–96. © 2006 Wiley‐Liss, Inc.