Details

Autor(en) / Beteiligte

• Gérardy, Romaric
• Emmanuel, Noémie
• Toupy, Thomas
• Kassin, Victor‐Emmanuel
• Tshibalonza, Nelly Ntumba
• Schmitz, Michaël
• Monbaliu, Jean‐Christophe M.

Titel

Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges

Ist Teil von

• European journal of organic chemistry, 2018-06, Vol.2018 (20-21), p.2301-2351

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on current important societal challenges. These societal challenges include health/well‐being and sustainable development. Continuous flow chemistry has enabled significant advances for the manufacturing of pharmaceuticals, as well as for biomass valorization toward a biosourced chemical industry. Examples related to pharmaceutical production are herein focused on (a) the implementation of flow chemistry to reduce the occurrence of drug shortages, (b) continuous flow manufacturing of orphan drugs, (c) continuous flow preparation of active pharmaceuticals listed on the WHO list of essential medicines and (d) perspectives for the manufacturing of peptide‐based pharmaceuticals. Examples related to sustainable development are focused on the valorization of biosourced platform molecules. Besides positive impacts on societal challenges, this review also illustrates some of the potentially most threatening perspectives of continuous flow technology within the actual context of terrorism and drug abuse. This review discusses the impacts of continuous flow chemistry on current societal challenges. Examples related to health/well‐being include efforts (a) for reducing drug shortages, (b) for accessing orphan drugs, and (c) providing WHO essential medicines. Examples related to sustainable development focus on the valorization of biosourced platform molecules.