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This multicenter trial evaluated zoledronic acid versus placebo in men with osteoporosis for a primary end point of new morphometric vertebral fracture over 24 months. Zoledronic acid was associated with a significantly reduced risk of vertebral fracture.
Osteoporosis is an important cause of morbidity and mortality among men.
1
,
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Among persons older than 50 years of age, approximately 40% of all osteoporotic fractures worldwide occur in men.
3
Mortality after osteoporotic fracture is higher among men than among women.
2
,
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Previous studies involving men with osteoporosis have focused on the surrogate outcomes of bone mineral density and bone-turnover markers,
5
–
9
but data from double-blind, randomized studies assessing antifracture efficacy are lacking. In addition, given the low awareness of the disease,
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the development of guidelines for the detection and treatment of osteoporosis in men has been limited.
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Hence, there . . .