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Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis
Ist Teil von
The New England journal of medicine, 2011-11, Vol.365 (20), p.1886-1895
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2011
Quelle
MEDLINE
Beschreibungen/Notizen
In this double-blind, randomized trial, mycophenolate mofetil was superior to azathioprine for maintaining a renal response and preventing relapse in patients with lupus nephritis who had had a response to induction therapy.
Systemic lupus erythematosus is an autoimmune disorder often characterized by the development of glomerulonephritis.
1
Renal involvement remains the strongest predictor of morbidity and mortality among patients with lupus,
1
and despite improvements in the management of lupus, the incidence of end-stage renal disease has not declined.
2
Management of lupus nephritis consists of induction therapy to achieve remission and long-term maintenance therapy to prevent relapse, progression to end-stage renal disease, and death.
3
However, the options for long-term therapy remain controversial. Treatment options include glucocorticoids and the immunosuppressive agents cyclophosphamide, azathioprine, and mycophenolate mofetil. These drugs have considerable toxicity and are not effective . . .