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Vaccine desirability during an effectiveness trial of the typhoid fever polysaccharide Vi vaccine, Kolkata India
Ist Teil von
Human vaccines & immunotherapeutics, 2009-09, Vol.5 (9), p.614-620
Erscheinungsjahr
2009
Link zum Volltext
Beschreibungen/Notizen
Background: High rates of typhoid fever and the emergence of multi-drug resistant strains create a need for prevention efforts including vaccines. Socio-behavioral research can provide important data for participation in future trials and public health vaccination campaigns.
Design: A 3b phase clinical trial in Kolkata India including pre- and post-vaccination socio-behavioral surveys.
Methods: 700 households randomly selected 503 respondents (71.85%) completing both the pre- and post- closed-ended surveys. Data analysis included descriptive statistics, Pearson’s chi-square tests, independent t-tests, and stepwise logistic regression analysis. Four open-ended questions were included in the survey. These qualitative data were coded and reviewed for common themes and patterns.
Results: 47.9% of respondents were male. Ward 29 respondents included 32.4% Hindu and Ward 30 respondents were 99.0% Hindu. Lower rates of participation were found among Muslim respondents and those with post high school education. Lack of information and negative information affected participation. Joint decision-making within households increased participation rates.
Conclusions: Individuals’ decisions to participate or not participate in a vaccine trial entail a balance between individual beliefs, household dynamics, and socio-political influences. Efforts prior to vaccination trials need to develop strategies which address potential underlying mediators for belief systems as well as structural factors which may reinforce individuals’ beliefs and perceptions about vaccination trials.