Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ginsenoside Rg 3 promotes inflammation resolution through M2 macrophage polarization
Ist Teil von
Journal of ginseng research, 2018-01, Vol.42 (1), p.68-74
Ort / Verlag
Korea (South)
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation.
Mouse peritoneal macrophages were polarized into M1 or M2 phenotypes. Reverse transcription-polymerase chain reaction, Western blotting, and measurement of nitric oxide (NO) and prostaglandin E
levels were performed
and in a zymosan-induced peritonitis C57BL/6 mouse model.
Ginsenoside Rg
was identified as a proresolving ginseng compound based on the induction of M2 macrophage polarization. Ginsenoside Rg
not only induced the expression of
(a representative M2 marker gene), but also suppressed M1 marker genes, such as
, and NO levels. The proresolving activity of ginsenoside Rg
was also observed
in a zymosan-induced peritonitis model. Ginsenoside Rg
accelerated the resolution process when administered at peak inflammatory response into the peritoneal cavity.
These results suggest that ginsenoside Rg
induces the M2 polarization of macrophages and accelerates the resolution of inflammation. This finding opens a new avenue in ginseng pharmacology.
Sprache
Englisch; Koreanisch
Identifikatoren
ISSN: 1226-8453
eISSN: 2093-4947
Titel-ID: cdi_kisti_ndsl_JAKO201809951100555
Format
–
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von bX