Details

Autor(en) / Beteiligte

• Huang, Chun
• Wang, Wei-Min
• Gong, Jian-Ping
• Yang, Kang

Titel

Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma

Ist Teil von

• Asian Pacific journal of cancer prevention : APJCP, 2013, Vol.14 (5), p.2699-2701

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thus may serve as a potential diagnostic marker for cancer cells in circulation. This mini-review aims to summarise information on Ras-induced oncogenesis and the clinical significance of K-ras.