Details

Autor(en) / Beteiligte

• Hyun, Tae-Kyung
• Kumar, Kundan
• Rao, Kudupudi Prabhakara
• Sinha, Alok Krishna
• Roitsch, Thomas

Titel

Role of ${\alpha}$-tocopherol in cellular signaling: ${\alpha}$-tocopherol inhibits stress-induced mitogen-activated protein kinase activation

Ist Teil von

• Plant biotechnology reports, 2011, Vol.5 (1), p.19-25

Erscheinungsjahr

2011

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• Tocopherols belong to the plant-derived poly phenolic compounds known for antioxidant functions in plants and animals. Activation of mitogen-activated protein kinases (MAPK) is a common reaction of plant cells in defense-related signal transduction pathways. We report a novel non-antioxidant function of ${\alpha}$-tocopherol in higher plants linking the physiological role of tocopherol with stress signalling pathways. Pre-incubation of a low concentration of $50{\mu}M$ ${\alpha}$-tocopherol negatively interferes with MAPK activation in elicitor-treated tobacco BY2 suspension culture cells and wounded tobacco leaves, whereas pre-incubated BY2 cells with ${\alpha}$-tocopherol phosphate did not show the inhibitory effect on stimuli-induced MAPK activation. The decreased MAPK activity was neither due to a direct inhibitory effect of ${\alpha}$-tocopherol nor due to the induction of an inhibitory or inactivating activity directly affecting MAPK activity. The data support that the target of ${\alpha}$-tocopherol negatively regulates an upstream component of the signaling pathways that leads to stress dependent MAPK activation.