Details

Autor(en) / Beteiligte

• Xu, Ming-Lu
• Choi, Jae-Young
• Jeong, Byeong-Seon
• Li, Gao
• Lee, Kap-Rang
• Lee, Chong-Soon
• Woo, Mi-Hee
• Lee, Eung-Seok
• Jahng, Yurng-Dong
• Chang, Hyeun-Wook
• Lee, Seung-Ho
• Son, Jong-Keun

Titel

Cytotoxic Constituents Isolated from the Fruit Bodies of Hypsizigus marmoreus

Ist Teil von

• Archives of pharmacal research, 2007, Vol.30 (1), p.28-33

Erscheinungsjahr

2007

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of $(22E,24R)-ergosta-7,22-diene-3{\beta},5{\alpha},6{\beta}-triol$ (1), $ergosterol-3-O-{\beta}-D-glucopyranoside$ (2), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta}-ol$ (3), hypsiziprenol $A_9$ (4), hypsiziprenol $AA_8$ (5), hypsiziprenol $AA_9$ (6) and hypsiziprenol $BA_{10}$ (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.