Details

Autor(en) / Beteiligte

• Ladurner, R.
• Hochleitner, B.
• Schneeberger, S.
• Barnas, U.
• Krismer, A.
• Kleinsasser, A.
• Offner, F.
• Königsrainer, I.
• Margreiter, R.
• Königsrainer, A.

Titel

Extended Liver Resection and Hepatic Ischemia in Pigs: A New, Potentially ReversibleModel to Induce Acute Liver Failure and Study Artificial Liver Support Systems

Ist Teil von

• European surgical research, 2005-12, Vol.37 (6), p.365-369

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background: Extended hepatectomy is a valid model for the study of acute liver failure. Since the porcine liver is comparable in size, morphology and anatomy to the human liver, we describe a technique employing hepatic ischemia and extended liver resection to induce acute liver failure in a porcine model as a means of studying bioartificial liver support. Method: A subtotal (75–80% resection) extended left hepatectomy was performed in 7 pigs after 60 min warm ischemia of the future remnant liver. After resection, the animals were given the best supportive care and observed until death. Results: All animals died within 18–48 h, none as a result of surgical complications. Gross appearance of the liver showed severe steatosis of the right lateral lobe, and histology revealed severe coagulative necrosis of the whole lobule. Conclusion: This technique of extended liver resection after hepatic ischemia in the porcine model may be useful for studies of potentially reversible acute liver failure and experimental bioartificial support.