Details

Autor(en) / Beteiligte

• Martin, James C.
• Wartell, Roger M.
• O'Shea, Donald C.

Titel

Conformational Features of Distamycin-DNA and Netropsin-DNA Complexes by Raman Spectroscopy

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1978-11, Vol.75 (11), p.5483-5487

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1978

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The binding of distamycin and netropsin to duplex DNA has been studied by Raman spectroscopy. Several changes occur in the Raman spectra of these drugs upon binding DNA. These changes were analyzed by assigning specific motions to the observed Raman bands through the use of molecular subunits of the drugs and normal mode calculations. Our analysis indicates that pyrrole ring and peptide group vibrations are altered upon binding to DNA. The environments of the pyrrole ring methyl groups are not affected by the binding. These data provide physical evidence consistent with a binding model in which the methyl groups on the pyrroles project away from the DNA and the peptide N-H groups form hydrogen bonds with the DNA.