Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12073-12078
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis of the thapsigargins
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12073-12078
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2004
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.0403300101Titel-ID: cdi_jstor_primary_3373092
- Format
- –
- Schlagworte
- Alcohols, Aldehydes, Apiaceae - chemistry, Biological Products - chemical synthesis, Biological Products - chemistry, Chemical synthesis, Chemistry, Chemistry, Organic - methods, Chlorides, Esters, Ethers, Hydrides, Ketones, Materials, Molecular Structure, Natural Product Synthesis Special Feature, Oxidation, Physical Sciences, Stereochemistry, Stereoisomerism, Thapsigargin - analogs & derivatives, Thapsigargin - chemical synthesis, Thapsigargin - chemistry