Details

Autor(en) / Beteiligte

• Benner, Eric J.
• Mosley, R. Lee
• Destache, Chris J.
• Lewis, Travis B.
• Jackson-Lewis, Vernice
• Gorantla, Santhi
• Nemachek, Craig
• Green, Steven R.
• Przedborski, Serge
• Gendelman, Howard E.
• Bloom, Floyd E.

Titel

Therapeutic Immunization Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (25), p.9435-9440

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.