Details

Autor(en) / Beteiligte

• Kim, Shinyop
• Ross N. A. La Motte-Mohs
• Rudolph, Dorothea
• Zúñiga-Pflücker, Juan Carlos
• Mak, Tak W.

Titel

The Role of Nuclear Factor-κB Essential Modulator (NEMO) in B Cell Development and Survival

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (3), p.1203-1208

Ort / Verlag

National Academy of Sciences

Erscheinungsjahr

2003

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The transcription factor nuclear factor-κB (NF-κB) is essential for immune and inflammatory responses. NF-κB essential modulator (NEMO) is a scaffolding component of the IκB kinase complex required for NF-κB activation in vitro. Because NF-κB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(-/-) mice die very early during embryogenesis, and fetal livers from NEMO(-/-) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(-/-) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival.