Details

Autor(en) / Beteiligte

• Seo, Mihwa
• Seo, Keunhee
• Hwang, Wooseon
• Koo, Hee Jung
• Hahm, Jeong-Hoon
• Yang, Jae-Seong
• Han, Seong Kyu
• Hwang, Daehee
• Kim, Sanguk
• Jang, Sung Key
• Lee, Yoontae
• Nam, Hong Gil
• Lee, Seung-Jae V.

Titel

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling inCaenorhabditis elegans

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (31), p.E4246-E4255

Ort / Verlag

National Academy of Sciences

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan ofCaenorhabditis elegans. In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. We find that HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) and is sufficient for extending lifespan. We further show that the expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes. Thus, the RNA helicase HEL-1 appears to promote longevity in response to decreased IIS as a transcription coregulator of DAF-16. Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans.