Details

Autor(en) / Beteiligte

• Peoples, George E.
• Goedegebuure, Peter S.
• Smith, Roy
• Linehan, David C.
• Yoshino, Ichiro
• Eberlein, Timothy J.

Titel

Breast and Ovarian Cancer-Specific Cytotoxic T Lymphocytes Recognize the Same HER2/Neu-Derived Peptide

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1995-01, Vol.92 (2), p.432-436

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1995

Quelle

MEDLINE

Beschreibungen/Notizen

• The identification of antigenic peptides presented on the tumor cell surface by HLA class I molecules and recognized by tumor-specific cytotoxic T lymphocytes may lead to a peptide vaccine capable of inducing protective cellular immunity. We demonstrate that both HLA-A2-restricted breast and ovarian tumor-specific cytotoxic T lymphocytes recognize shared antigenic peptides. At least one of these peptides is derived from the oncogene product of HER2/neu, which is overexpressed in 30-40% of all breast and ovarian cancers. T cells sensitized against this nine-amino acid sequence demonstrate significant recognition of HLA-A2+, HER2/neu+tumors. Since 50% of the tumor-cell population is HLA-A2+and many different tumors express HER2/neu, this peptide may be widely recognized and have many clinical applications.