Details

Autor(en) / Beteiligte

• TOBIKI, HISAO
• SHIMAGO, KOZO
• UEDA, SHINJI

Titel

Studies on β-Lactam Antibiotics. I. On the Reactivity of D-3-Acetoacetyl-4-phenyl-2, 5-oxazolidinedione

Ist Teil von

• YAKUGAKU ZASSHI, 1980/01/25, Vol.100(1), pp.29-33

Ort / Verlag

The Pharmaceutical Society of Japan

Erscheinungsjahr

1980

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The reactivity of D-3-acetoacetyl-4-phenyl-2, 5-oxazolidinedione (III) was investigated. Reaction of D-4-phenyl-2, 5-oxazolidinedione (II) with diketene in the presence of a catalytic amount of hydrogen chloride afforded III, which was converted to D-6-methyl-2, 4-dioxo-α-phenyl-2H-1, 3-oxazine-3 (4H)-acetic acid (VI) with sodium bicarbonate. D (-)-α-Aminobenzylpenicillin was prepared by reacting 6-aminopenicillanic acid with III, followed by removal of the protecting group.