Details

Autor(en) / Beteiligte

• Iwase, Masanori
• Nohara, Sakae
• Sasaki, Nobuhiro
• Himeno, Toshitaka
• Nishida, Mariko
• Yoshinari, Mototaka
• Yoshizumi, Hideyuki
• Mukai, Naoko
• Doi, Yasuftimi
• Morizono, Shigeaki
• Asano, Tamotsu
• Tsutsu, Nobutaka
• Iida, Mitsuo

Titel

Pharmacokinetics Study of Low Dose of Metformin Clinically Used in Japan

Ist Teil von

• Journal of the Japan Diabetes Society, 2004/03/30, Vol.47(3), pp.197-201

Ort / Verlag

THE JAPAN DIABETES SOCIETY

Erscheinungsjahr

2004

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• We conducted pharmacokinetic studies after oral administration of 250 mg metformin to reexamine its dose-setting in Japan, where the maximum dose is limited to 750 mg daily.Tmax was 4 hrs in healthy controls (n=6) and diabetic patients (n=5).Cmax was 0.54±0.15μg/ml in control and 0.85±0.19 μg/ml in diabetic patients, consistent with data reported in the English literature.In repetitive administration of 500 mg metformin daily for 7 days, serum concentration of metformin reached the steady state on day 3, and the profile of metformin concentration on day 7 fitted well with the concentration curve predicted by that on day 1.No significantdifferences were seen in Tmax, Cmax, or T1/2 on days 1 and 7.We report the pharmacokinetics of metformin at the dose set in Japan.