Details

Autor(en) / Beteiligte

• YOSHIMOTO, Sho
• KATO, Daiki
• KAMOTO, Satoshi
• YAMAMOTO, Kie
• TSUBOI, Masaya
• SHINADA, Masahiro
• IKEDA, Namiko
• TANAKA, Yuiko
• YOSHITAKE, Ryohei
• ETO, Shotaro
• SAEKI, Kohei
• CHAMBERS, James
• HASHIMOTO, Yuko
• UCHIDA, Kazuyuki
• NISHIMURA, Ryohei
• NAKAGAWA, Takayuki

Titel

Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer

Ist Teil von

• Journal of Veterinary Medical Science, 2020, pp.20-0026

Ort / Verlag

JAPANESE SOCIETY OF VETERINARY SCIENCE

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Human epidermal growth factor receptor 2 (HER2) overexpression has been reported in various human cancers. HER2-targeted therapies showed clinical responses in humans with HER2-positive tumors. The incidence of canine primary lung cancer (cPLC) is increasing, but there are no effective systemic therapies for dogs with late-stage cPLC. HER2-targeted therapy could be an option for cPLC, but HER2 expression in cPLC remains unknown. We evaluated HER2 expression in cPLC. Immunohistochemical analysis revealed that 3 samples (19%) scored 3+; 8 (50%), 2+; 5 (31%); and 1+ and 0 (0%), 0. Of the cPLC tissues, 69% were HER2 positive (scored ≥2+). These data would lead to further evaluation of the role of HER2 in cPLC as a mechanism of malignancy and therapeutic target.