Details

Autor(en) / Beteiligte

• Heyrman, R. M.
• De Backer, W. A.
• Van Waeleghem, J. P.
• De Broe, M. E.

Titel

The Effect of Acetate on Ventilation in Haemodialysis Patients

Ist Teil von

• Nephrology, dialysis, transplantation, 1989, Vol.4 (12), p.1060-1064

Ort / Verlag

Oxford University Press

Erscheinungsjahr

1989

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This study evaluates the direct effect of acetate upon ventilation during acetate-haemodialysis. Eight patients with end-stage renal failure who were receiving chronic haemodialysis treatment underwent acetate infusion for 1 h on a day outside a haemodialysis session. Ventilation was continuously measured using respiratory inductance plethysmography, starting 20min before the infusion. Arterial blood samples were drawn and expired gases were analysed at regular intervals. After 1 h of acetate infusion, arterial pH increased rapidly and significantly from 7.38±0.01 to 7.49±0.01, the Vco2 and Vo2 slightly decreased and increased respectively, resulting in a reduced respiratory exchange ratio from 0.81±0.04 to 0.69±0.05. Ventilation slightly decreased only after 60 min, whereas the breathing pattern remained normal; neither apnoea periods nor periodic breathing were observed. We conclude that the hypoventilation and irregular breathing encountered in acetate-cuprophane haemodialysis is related to CO2/HCO3− unloading and the occurrence of complement-activation-induced hypoxaemia rather than to the small changes in Vco2, Vo2 during metabolism of acetate.