Details

Autor(en) / Beteiligte

• Nguyen, Hoai Nam
• Tran Thi, Hong Ha
• Quang, Duong Le
• Thi, Toan Nguyen
• Tran Thi, Nhu Hang
• Le, Mai Huong
• Ha, Phuong Thu

Titel

Apoptosis induced by paclitaxel-loaded copolymer PLA-TPGS in Hep-G2 cells

Ist Teil von

• Advances in natural sciences. Nanoscience and nanotechnology, 2012-10, Vol.3 (4), p.45005

Ort / Verlag

IOP Publishing

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Paclitaxel is an important anticancer drug in clinical use for treatment of a variety of cancers. The clinical application of paclitaxel in cancer treatment is considerably limited due to its serious poor delivery characteristics. In this study paclitaxel-loaded copolymer poly(lactide)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) nanoparticles were prepared by a modified solvent extraction/evaporation technique. The characteristics of the nanoparticles, such as surface morphology, size distribution, zeta potential, solubility and apoptosis were investigated in vitro. The obtained spherical nanoparticles were negatively charged with a zeta potential of about −18 mV with the size around 44 nm and a narrow size distribution. The ability of paclitaxel-loaded PLA-TPGS nanoparticles to induce apoptosis in human hepatocellular carcinoma cell line (Hep-G2) indicates the possibility of developing paclitaxel nanoparticles as a potential universal cancer chemotherapeutic agent.