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Integrated Cantilever-Based Biosensors for the Detection of Chemical and Biological Entities
Ist Teil von
Nanotechnology in Biology and Medicine, 2018, p.469-530
Auflage
2
Ort / Verlag
CRC Press
Erscheinungsjahr
2018
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Microcantilever sensors can be largely divided by the operation mode and the measurement environment. The operation mode of microcantilever sensors can be either the static mode based on the cantilever deflection or the dynamic mode based on the resonant frequency. The measurement environment often determines the type of sample entities and limits the sensitivity of the microcantilever sensor. The measurement environment can be in vacuum, in air, or in liquid. In this chapter, the microcantilever sensors in each category will be reviewed and one exemplary work will be discussed in further detail.
In the last decade, numerous microcantilever sensors have been developed to detect various chemical and biological entities. Microcantilever sensors can be largely divided by the operation mode and the measurement environment. The operation mode of microcantilever sensors can be either the static mode based on the cantilever deflection or the dynamic mode based on the resonant frequency. Integrated microsystem is an area of intense interest and has proven to be an arena where different fields can participate and provide their expertise and unique contributions. Microscale cantilever beams were first introduced to the nanotechnology field with their use as force sensors in atomic force microscopy (AFM). Decreasing the overall dimensions of the cantilever beam leads to an increase in its mechanical sensitivity to perturbations from the surroundings. Single-crystal materials are preferred materials to make sensor elements due to their high mechanical quality factor. Piezoelectric effect is the phenomenon of transient charges being induced due to mechanical strain or deformation.