Details

Autor(en) / Beteiligte

• Glowacki, Robert W. P.
• Martens, Eric C.
• Faiz, Saadia A.
• Bawa, Raj
• Audette, Gerald F.
• Diwan, Anil
• Chang, Esther H.

Titel

In Sickness and Health: Effects of Gut Microbial Metabolites on Human Physiology

Ist Teil von

• Advances in Medical Biochemistry, Genomics, Physiology, and Pathology, 2022, p.617-628

Auflage

1

Ort / Verlag

Jenny Stanford Publishing

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The connection between intestinal microbes and human health has been appreciated since the 1880s with Theodor Escherich's investigation of Escherichia coli and other fecal bacteria. Escherich hypothesized that indigenous micoorganisms play roles in both digestion and intestinal diseases. This chapter highlights provide details that underscore the importance of gut microbes in human health, which Escherich postulated long ago. The collective diversity of microbial species that compose the gut microbiome harbor approximately 10 million unique, annotated genes-probably many more -that are not present in the human genome. A recent example highlights how the common gut commensal Bacteroides thetaiotaomicron and related Bacteroidetes metabolize a range of xenobiotics using previously undescribed mechanisms. Some of the findings described can be leveraged to design tools to guide drug selection and therapeutic interventions. Leveraging the results of functional studies that link the microbiome to these diseases will illuminate new paths to manipulate the potential deleterious effects of the gut microbiome on health.