Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Use of suicide genes for cancer gene therapy: study of the different approaches
Ist Teil von
Expert opinion on biological therapy, 2004-04, Vol.4 (4), p.519-530
Ort / Verlag
England: Ashley Publications Ltd
Erscheinungsjahr
2004
Link zum Volltext
Quelle
Taylor & Francis
Beschreibungen/Notizen
Cancer is a disease of high incidence for which conventional treatments are not necessarily effective. There is a need for the development of new alternative strategies. Among them, suicide gene therapy has been developed. In this approach, a gene encoding for a protein toxic under particular conditions is delivered to the target cells, resulting in their death. Although this approach has been in development for a long time, new combinations with other gene therapy areas, such as selective replicative viruses, tumour targeting, or conventional treatments such as chemo- or radiotherapy, are currently being tested. This review will summarise some of these approaches.