Details

Autor(en) / Beteiligte

• Zhou, Dong-Mei
• Shen, Mengyuan
• Ke, Lv
• Zhang, Zi-Lin
• Zhang, Kai-Zhe
• Zhang, Shenghui
• Wang, Yanqing
• Yang, Hao-Ran
• Tang, Daoyuan
• Huang, Donghui
• Yang, Jin-Kui
• Xu, Huan

Titel

Strong and osteoconductive poly(lactic acid) biocomposites by high-shear liquid dispersion of hydroxyapatite nanowhiskers

Ist Teil von

• Nanocomposites, 2022-12, Vol.8 (1), p.24-33

Ort / Verlag

Abingdon: Taylor & Francis

Erscheinungsjahr

2022

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Controlled incorporation of bioactive hydroxyapatite (HA) into poly(lactic acid) (PLA) signifies a promising approach to design and development of biomedical-adaptive materials. Here we unravel a microwave-assisted biomineralization approach to synthesis of HA nanowhiskers (HANWs), which were characterized by well-controlled diameter (∼30 nm) and length (80 − 120 nm), combined with a desirable calcium − phosphorus ratio (Ca/P) of 1.67. A high-shear liquid dispersion (HSLD) method that provided a combination of high pressure (up to 50 kPa) and high shear rate approaching 10000 s −1 was established to fabricate homogeneous PLA/HANWs composites. In particular, upon incorporation of 30 wt % HANWs the tensile strength and elastic modulus of PLA-HA30 (76.7 MPa and 3.3 GPa) were elevated by 48% and 84% compared to those of pure PLA, respectively, as accompanied by a nearly 2-fold increase in the cell viability. This work paves a facile yet effective roadway to strong and osteoconductive PLA composites appealing for bone tissue repairing. Synopsis: Biomineralization concepts are abstracted to synthesize well-defined and bioactive HANWs, which could be uniformly dispersed in PLA biofilms by high-shear liquid exfoliation.