Details

Autor(en) / Beteiligte

• Gerlach, Aaron C
• Antonio, Brett M

Titel

Validation of ion channel targets

Ist Teil von

• Channels (Austin, Tex.), 2015-11, Vol.9 (6), p.376-379

Ort / Verlag

United States: Taylor & Francis Group, LLC

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A prerequisite for a successful target-based drug discovery program is a robust data set that increases confidence in the validation of the molecular target and the therapeutic approach. Given the significant time and resource investment required to carry a drug to market, early selection of targets that can be modulated safely and effectively forms the basis for a strong portfolio and pipeline. In this article we present some of the more useful scientific approaches that can be applied toward the validation of ion channel targets, a molecular family with a history of clinical success in therapeutic areas such as cardiovascular, respiratory, pain and neuroscience.