Details

Autor(en) / Beteiligte

• Zhu, Seng
• Victoria, Guiliana Soraya
• Marzo, Ludovica
• Ghosh, Rupam
• Zurzolo, Chiara

Titel

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

Ist Teil von

• Prion, 2015-03, Vol.9 (2), p.125-135

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases caused by the misfolding of the cellular prion protein to an infectious form PrP Sc . The intercellular transfer of PrP Sc is a question of immediate interest as the cell-to-cell movement of the infectious particle causes the inexorable propagation of disease. We have previously identified tunneling nanotubes (TNTs) as one mechanism by which PrP Sc can move between cells. Here we investigate further the details of this mechanism and show that PrP Sc travels within TNTs in endolysosomal vesicles. Additionally we show that prion infection of CAD cells increases both the number of TNTs and intercellular transfer of membranous vesicles, thereby possibly playing an active role in its own intercellular transfer via TNTs.