Details

Autor(en) / Beteiligte

• Gomes, Ana Carolina
• Borges, Alexandre
• Zoca, Daniela Garcia
• Silva, Marcio Luís Andrade e
• Machado, Aline Rafaela da Silva Rodrigues
• Machado, Alex Martins
• Santos, Mario F. C.
• de Laurentiz, Rosangela da Silva

Titel

Larvicidal potential of extracts and isolated compounds from Piper cubeba fruits against Aedes aegypti (Diptera: Culicidae) larvae

Ist Teil von

• Natural Product Research, 2023, Vol.37 (16), p.2787-2794

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aedes aegypti is the primary vector of virus transmission that causes dengue, yellow fever, chikungunya and zika. The primary prevention method has been vector control and synthetic insecticides that can cause environmental side effects. Thus, the work aimed to evaluate the larvicidal potential of extracts and isolated compounds from Piper cubeba against A. aegypti larvae. The larvicidal activity method was executed according to the World Health Organization protocol. The larvae were analyzed by scanning electron microscopy (SEM). Through molecular docking, the action mechanism was investigated. The hydroalcoholic and hexane extracts showed similar larvicidal activity with LC 50 of 191.1 μg/mL and 185.84 μg/mL, respectively. Between isolated compounds, hinokinin presented LC 50 = 97.74 μg/mL. The SEM analysis showed structural damage to the larva's tegument caused by extracts and isolated compounds. Therefore, the results demonstrate the larvicidal action of hinokinin and extracts, which can lead to the development of new natural larvicides.