Details

Autor(en) / Beteiligte

• Chen, Lei
• Teng, Hui
• Jia, Zhen
• Battino, Maurizio
• Miron, Anca
• Yu, Zhiling
• Cao, Hui
• Xiao, Jianbo

Titel

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

Ist Teil von

• Critical reviews in food science and nutrition, 2018-11, Vol.58 (17), p.2908-2924

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.