Details

Autor(en) / Beteiligte

• Bañares, Angelo B.
• Nisola, Grace M.
• Valdehuesa, Kris N. G.
• Lee, Won-Keun
• Chung, Wook-Jin

Titel

Engineering of xylose metabolism in Escherichia coli for the production of valuable compounds

Ist Teil von

• Critical reviews in biotechnology, 2021-07, Vol.41 (5), p.649-668

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2021

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• The lignocellulosic sugar d-xylose has recently gained prominence as an inexpensive alternative substrate for the production of value-added compounds using genetically modified organisms. Among the prokaryotes, Escherichia coli has become the de facto host for the development of engineered microbial cell factories. The favored status of E. coli resulted from a century of scientific explorations leading to a deep understanding of its systems. However, there are limited literature reviews that discuss engineered E. coli as a platform for the conversion of d-xylose to any target compounds. Additionally, available critical review articles tend to focus on products rather than the host itself. This review aims to provide relevant and current information about significant advances in the metabolic engineering of d-xylose metabolism in E. coli. This focusses on unconventional and synthetic d-xylose metabolic pathways as several review articles have already discussed the engineering of native d-xylose metabolism. This paper, in particular, is essential to those who are working on engineering of d-xylose metabolism using E. coli as the host.