Details

Autor(en) / Beteiligte

• Lukusa, Aimé Kazadi
• Vermylen, Christiane
• Vanabelle, Bernard
• Curaba, Mara
• Brichard, Benedicte
• Chantrain, Christophe
• Dupont, Sophie
• Ferrant, Augustin
• Wyns, Christine

Titel

BONE MARROW TRANSPLANTATION OR HYDROXYUREA FOR SICKLE CELL ANEMIA: Long-Term Effects on Semen Variables and Hormone Profiles

Ist Teil von

• Pediatric hematology and oncology, 2009-01, Vol.26 (4), p.186-194

Ort / Verlag

England: Informa UK Ltd

Erscheinungsjahr

2009

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Ten male subjects affected by sickle cell anemia (SCA) were studied to evaluate the long-term effects of therapies on their fertility. Their ages ranged from 18 to 34 years (median: 32 years). Four subjects were treated by hydroxyurea (HU) and 6 by hematopoietic stem cell transplantation (HSCT). The median follow-up after HU initiation and HSCT was 10.5 years (range: 8-15 years) and 15.5 years (range: 8-21 years), respectively. Three of the 6 in the HSCT group and two of the 4 in the HU group were azoospermic. One HSCT subject had normal semen and hormone variables, showing that normal fertility can occasionally be expected after transplantation in SCA. The remaining 4 patients (2 HSCT and 2 HU) were oligozoospermic. With regard to HU, semen impairment appears to be related to the duration of treatment. To draw general conclusions, further research with a large number of patients treated since childhood with HU or HSCT is warranted.