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Efficacy of Methylprednisolone pulse therapy versus Infliximab in the treatment of severe flares of chronic polyarthritis
Ist Teil von
Scandinavian journal of rheumatology, 2001, Vol.30 (6), p.335-339
Ort / Verlag
Colchester: Informa UK Ltd
Erscheinungsjahr
2001
Link zum Volltext
Quelle
Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
Background : To compare short term efficacy of pulse intravenous (iv) Methylprednisolone (MP) versus Infiximab in flares of polyarthritis. Patients-methods : Observational study of consecutive patients admitted with flares of chronic polyarthritis. Treatment consisted of three iv doses of MP 1000 mg on alternate days (MP-group, n = 10) or of Infliximab will be 3 mg/kg at baseline, two, and six weeks later (I-group, n = 9). DMARD therapy was initiated/continued in all patients. Disease parameters at baseline (t = 0), two weeks (t = 1) and twelve weeks (t = 2) were compared by non-parametric testing. Results : Reductions in disease parameters at both t = 1 and t = 2, the occurrence of side effects and the proportion of patients reaching ACR 20, 50 or 70% response criteria were similar in both groups. Conclusion : Pulse MP resulted in a symptomatic response similar to Infliximab in our patients. The benefit of MP was observed for up to 3 months.