Details

Autor(en) / Beteiligte

• Lker Durak, Muammer Karaayvaz, Mustafa Kavutcu, M. Y. Burak Cimen, Murat Kacmaz, Serap Buyukkocak, H. Serdar Ozturk

Titel

REDUCED ANTIOXIDANT DEFENSE CAPACITY IN MYOCARDIAL TISSUE FROM GUINEA PIGS TREATED WITH 5-FLUOROURACIL

Ist Teil von

• Journal of Toxicology and Environmental Health, Part A, 2000-04, Vol.59 (7), p.585-589

Ort / Verlag

London: Informa UK Ltd

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Antioxidant defense capacity was investigated in myocardial tissue from guinea pigs treated with 5-fluorouracil (5-FU) at a dose of 400 mg/kg/d daily for 5 d administered intraperitonally. Treatment with 5-FU lowered the activities of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) accompanied by higher catalase (CAT) activity. Further, antioxidant potential (AOP) values were lower but oxidation resistance (OR) and malondialdehyde (MDA) levels were higher in the 5-FU-treated tissue. With regard to myocardial iron (Fe) and copper (Cu) levels, no significant differences were found between the groups. Results suggest that 5-FU treatment causes impairment in the myocardial antioxidant defense system and leads to cardiac peroxidation. It has been postulated that these changes might be responsible for the 5-FU cardiotoxicity seen in some patients, and antioxidant therapy might provide a therapeutic advantage.