Details

Autor(en) / Beteiligte

• Fu, Y.X.
• Wang, Y.H.
• Tong, X.S.
• Gong, Z.
• Sun, X.M.
• Yuan, J.C.
• Zheng, T.T.
• Li, C.
• Niu, D.Q.
• Dai, H.G.
• Liu, X.F.
• Mao, Y.J.
• Tang, B.D.
• Xue, W.
• Huang, Y.J.

Titel

EDACO, a derivative of myricetin, inhibits the differentiation of Gaoyou duck embryonic osteoclasts in vitro

Ist Teil von

• British poultry science, 2019-03, Vol.60 (2), p.169-175

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2019

Quelle

Taylor & Francis

Beschreibungen/Notizen

• 1. This study determined the effects of (E)-3-(2-(4-(3-(2,4-dimethoxyphenyl)acryloyl)phenoxy)ethoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (EDACO) on the differentiation of Gaoyou duck embryonic osteoclasts cultured in vitro. 2. Bone marrow mononuclear cells (BM-MNC) were collected from 23-d-old Gaoyou duck embryos and induced by macrophage colony-stimulating factor and receptor activator of nuclear factor κB ligand in the presence of EDACO at different concentrations (i.e. 10, 20, 40, 80 and 160 µM). Tartrate-resistant acid phosphatase (TRAP) staining and resorption ability determination were conducted. 3. Results suggested that EDACO suppressed the shaping of positive multinucleated cells and the number of TRAP-positive cells in the 20, 40, 80 and 160 μM EDACO groups was significantly decreased (P < 0.05 or P < 0.01). Besides, the absorption activity of differentiated duck embryonic osteoclasts was significantly inhibited (P < 0.05) in both 80 and 160 μM EDACO groups. 4. Overall, EDACO can inhibit the differentiation of BM-MNC into mature osteoclasts in duck embryos.1