Details

Autor(en) / Beteiligte

• Alfredo Guarnieri, Alessandro Neri, Pier Paolo Correale, Michele Lottini, Michele Testa, Federico Mariani, Enrico Tucci, Tiziana Megha, Marcella Cintorino, Alfonso Carli

Titel

Prediction of Lymph Node Status by Analysis of Prognostic Factors and Possible Indications for Elective Axillary Dissection in T1 Breast Cancers

Ist Teil von

• The European journal of surgery, 2001-04, Vol.167 (4), p.255-259

Ort / Verlag

Informa UK Ltd

Erscheinungsjahr

2001

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective: To identify those patients with T1 breast cancers with lower risk of nodal metastases who can safely be spared axillary dissection. Design: Retrospective study. Setting: University hospital, Italy. Subjects: Review of clinical records and histopathological slides of 547 patients with T1 breast cancer, operated on between 1984 and 1997. Main outcome measures: Incidence of axillary metastases in relation to age, menopausal status, diameter and grade of tumour, vascular invasion, DNA ploidy, S-phase fraction and hormone receptor state, by univariate and multivariate analysis. Results: Axillary metastases were present in 159 patients (29%). On univariate analysis, diameter of tumour 10 mm or less (pT1a/pT1b cancers), no vascular invasion, and grade 1 tumour were significantly correlated with a lower risk of nodal metastases, but only vascular invasion (p = 0.0001, odds ratio = 3.1) and diameter of tumour (p = 0.04, odds ratio = 1.6) were independent predictors on multivariate analysis. Among 34 pT1a/pT1b cancers, with low grade of tumour and no vascular invasion, only 2 (6%) had axillary metastases. When only one favourable predictive factor was associated with diameter of tumour of 10 mm or less, the incidence of axillary metastases ranged from 12% for 43 patients with grade 1 cancers to 13% for 76 patients with no vascular invasion. Conclusions: