Details

Autor(en) / Beteiligte

• Tucci, Alessandra
• Martelli, Maurizio
• Rigacci, Luigi
• Riccomagno, Paola
• Cabras, Maria Giuseppina
• Salvi, Flavia
• Stelitano, Caterina
• Fabbri, Alberto
• Storti, Sergio
• Fogazzi, Stefano
• Mancuso, Salvatrice
• Brugiatelli, Maura
• Fama, Angelo
• Paesano, Paolo
• Puccini, Benedetta
• Bottelli, Chiara
• Dalceggio, Daniela
• Bertagna, Francesco
• Rossi, Giuseppe
• Spina, Michele

Titel

Comprehensive geriatric assessment is an essential tool to support treatment decisions in elderly patients with diffuse large B-cell lymphoma: a prospective multicenter evaluation in 173 patients by the Lymphoma Italian Foundation (FIL)

Ist Teil von

• Leukemia & lymphoma, 2015-04, Vol.56 (4), p.921-926

Ort / Verlag

United States: Informa Healthcare

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001). Survival in unfit and frail patients was not significantly different. Curative treatment slightly improved 2-year OS in unfit (75% vs. 45%) but not in frail patients (44% vs. 39%). CGA was confirmed as very efficient in identifying elderly patients with DLBCL who can benefit from a curative approach. Further efforts are needed to better tailor therapies in non-fit patients.