Details

Autor(en) / Beteiligte

• Bang, Peter
• Laursen, Inga
• Thornberg, Klaus
• Schierbeck, Jens
• Nielsen, Bjarne
• Valdimarsson, Helgi
• Koch, Claus
• Christiansen, Michael

Titel

The pharmacokinetic profile of plasma-derived mannan-binding lectin in healthy adult volunteers and patients with Staphylococcus aureus septicaemia

Ist Teil von

• Scandinavian journal of infectious diseases, 2008, Vol.40 (1), p.44-48

Ort / Verlag

Basingstoke: Informa UK Ltd

Erscheinungsjahr

2008

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Mannan-binding lectin (MBL) is a member of the innate immune system, and MBL-deficiency affects 10-15% of Caucasians. With development of a plasma-derived MBL, substitution has become a therapeutic option in diseases associated with MBL insufficiency. The pharmacokinetics of injected MBL is weakly described, particularly in patients with infectious diseases. The pharmacokinetic profile of MBL following administration of 0.08 mg/kg to 20 healthy MBL-deficient volunteers and 0.2 mg/kg to 2 patients with Staphylococcus aureus septicaemia was established. In the volunteers, the maximal concentration was 2849 µg/l; the mean half-life (T1/2) was 69.6 h (14.6-114.9 h). The normalized clearance was 9×10−6 l/min×kg, and the mean residence time was 82 h. In the patients the serum-MBL versus time curves were similar to those in the volunteers, and T1/2 values were 36 and 40 h. In conclusion, MBL is distributed into a median volume of 3.4 l similar to the plasma volume, and the elimination in septicaemic patients was within the range of the controls. Due to the large individual variation in T1/2, we recommend that MBL therapy, with respect to dose and infusion intervals, is based on the chosen therapeutic target (≥1000 µg/l) and MBL serum determinations following the first infusion.