Details

Autor(en) / Beteiligte

• Nguyen, Kevin P.
• Fatt, Cherise Chin
• Mellema, Cooper
• Trivedi, Madhukar H.
• Montillo, Albert

Titel

Sensitivity of Derived Clinical Biomarkers to rs-fMRI Preprocessing Software Versions

Ist Teil von

• 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), 2019, Vol.2019, p.1581-1584

Ort / Verlag

IEEE

Erscheinungsjahr

2019

Quelle

IEL

Beschreibungen/Notizen

• When common software packages (CONN and SPM) are used to process fMRI, results such as functional connectivity measures can substantially differ depending on the versions of the packages used and the tools used to convert image formats such as DICOM to NIFTI. The significance of these differences are illustrated within the context of a realistic research application: finding moderators of antidepressant response from a large psychiatric study of 288 major depressive disorder (MDD) patients. Significant differences in functional connectivity measurements and discrepancies in derived moderators were found between nearly all software configurations. These results should encourage researchers to be vigilant of software versions during fMRI preprocessing, to maintain consistency throughout each project, and to carefully report versions to facilitate reproducibility.