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The seven articles in this special section focus on agile radio resource management technologies for use in 5G mobile communications (5G). 5G networks will support a wide range of frequency bands, features, and use cases, with native support for efficient operation. 5G is considered as a significant disruptor to traditional mobile networks. Some of the main motivations behind the design, standardization, and deployment of the new generation of mobile networks include: significant increase of the supported data rates for enhanced mobile broadband, support for ultra-reliable and low-latency communications (URLLC), and support for massive machine type communications (mMTC). The combination of these 5G pillars can further enable new use cases, such as virtual or augmented reality (VR/AR), enabled by combining eMBB and URLLC.