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With the pace of urbanization continues to accelerate, making underground construction area is growing. More and more large underground public buildings are located in the ground, such as shopping malls, subways and so on. The fire evacuation in a large underground building has more difficulty than on the ground. In order to gain more time for evacuation, smoke design of large underground public buildings must meet certain requirements to evacuate. In this paper, a Guangzhou Metro Station, DaShaDi was taken for instance, based on engineering software Pyro Sim, analyzed a variety of working conditions of fire power and fire positions, the design of the exhaust system was checked in the subway station, got the best exhaust ventilation mode on fire condition.