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Radiation Portal Monitors (RPMs) are radiation detection devices which provide passive, non-intrusive means for fast screening of transportation of vehicles, baggage and passengers for the presence of nuclear and radiological materials. This paper presents two novel methods for enhancing the performances of RPMs. These methods are based on the analysis of the special pattern of the readings from the RPM detector. The pattern is generated when a moving radiation source is measured while the background is stagnant. This pattern provides an opportunity to employ methods based on the Matched Filter (MF) algorithm and the Generalized Likelihood Ratio Test (GLRT). Estimation of the radioactive source location in the vehicle improves the statistics furthermore.