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Application of a flow type quartz crystal microbalance immunosensor for detection of cartilage oligomeric matrix protein and α1-antitrypsin
Ist Teil von
2013 2nd International Symposium on Instrumentation and Measurement, Sensor Network and Automation (IMSNA), 2013, p.712-715
Ort / Verlag
IEEE
Erscheinungsjahr
2013
Link zum Volltext
Quelle
IEEE Electronic Library (IEL)
Beschreibungen/Notizen
Osteoarthritis (OA) is a chronic disease that often occurs in the elderly population. Currently, the most common methods for diagnosing OA are radiographs and enzyme-linked immunosorbent assay (ELISA) method which are specific but require specialized laboratory facilities and highly trained personal. In this work, it developed a user friendly and non-invasive method that is quartz crystal microbalance (QCM) immunosensor, which the biointerface was designed to immobilize antibody by self-assembled monolayer (SAM) technique on the QCM surface. Cartilage oligomeric matrix protein (COMP) and α1-antitrypsin (AAT) were used as antibodies. The developed QCM-based immunosensor for COMP and AAT detection showed good sensitivity, linearity (99.9%), specificity and reliability.