IEEE transactions on biomedical engineering, 2012-08, Vol.59 (8), p.2302-2311
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Novel Passive Element Circuits for Microdosimetry of Nanosecond Pulsed Electric Fields
- Ist Teil von
- IEEE transactions on biomedical engineering, 2012-08, Vol.59 (8), p.2302-2311
- Ort / Verlag
- United States: IEEE
- Erscheinungsjahr
- 2012
- Quelle
- IEEE Electronic Library Online
- Beschreibungen/Notizen
- Microdosimetric models for biological cells have assumed increasing significance in the development of nanosecond pulsed electric field technology for medical applications. In this paper, novel passive element circuits, able to take into account the dielectric dispersion of the cell, are provided. The circuital analyses are performed on a set of input pulses classified in accordance with the current literature. Accurate data in terms of transmembrane potential are obtained in both time and frequency domains for different cell models. In addition, a sensitivity study of the transfer function for the cell geometrical and dielectric parameters has been carried out. This analysis offers a new, simple, and efficient tool to characterize the nsPEFs' action at the cellular level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0018-9294eISSN: 1558-2531DOI: 10.1109/TBME.2012.2203133Titel-ID: cdi_ieee_primary_6213088
- Format
- –
- Schlagworte
- Biological system modeling, Biomembranes, Cell Membrane - physiology, Circuit models, Cytological Techniques - methods, Cytoplasm - physiology, dielectric dispersion, Dielectrics, Dispersion, Electromagnetic Fields, electroporation, Electroporation - methods, Frequency domain analysis, Integrated circuit modeling, Mathematical model, Membrane Potentials - physiology, microdosimetry, Models, Biological, Nanotechnology - methods, Radiometry - methods